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Hisworkhasnotbeenpublished."That'sthestory—it'sallcloakedinsecrecy,"saidbioethicistWilliamHurlbutofStanfordUniversityintheUnitedStates.HurlbutspokewithHeJiankuimanytimesbeforeHereportedonhisresearchataHongKongscienceconference.HeclaimedtohaveusedatoolcalledCRISPRtochangeageneinhumanembryos.HisgoalwastotrytohelptheembryosresistinfectionwiththevirusthatcausesthediseaseAIDS."Ifeelastrongresponsibilitythatit'snotjusttomakeafirst,butalsomakeitanexample,"HetoldTheAssociatedPresslastyear."Societywilldecidewhattodonext,"hesaid.Manyexpertsdenouncedhisworkasmedicallyunnecessaryandunethical.Theysaiditwasunclearwhatharmthechangesmighthavecaused.Sincethen,manyexpertshavecalledforbetterrulesorevenabanonsimilarwork.Butitisunclearwhowouldsetpoliciesandwhowouldenforcethem."Nothinghaschanged,"saidKiranMusunuru,ageneticistattheUniversityofPennsylvaniainPhiladelphia.MusunurujustpublishedabookaboutgeneeditingandthecaseoftheCRISPRbabies.WhereareHeJiankuiandthebabies?HeJiankuiwaslastseeninearlyJanuaryatanapartmentbuilding.Armedguardswerestandingnearby,leadingsometosuspecthewasunderhousearrest.Theuniversitydismissedhimfromhispositionwiththeschoolafterhisworkbecameknown.Afewweekslater,China'sofficialnewsagencysaidaninvestigationhadfoundthatHeactedaloneoutofdesireforfame.Italsosaidhewouldbepunishedforanyviolationsofthelaw.Sincethen,effortsbyTheAssociatedPresstoreachthescientisthavebeenunsuccessful.RyanFerrell,amediarelationspersonworkingforHe,refusedtocomment.WilliamHurlbut,whohasbeenincontactwithHeearlierthisyear,refusedtosaywhenhelastheardfromhim.AChineseinvestigationseemedtoconfirmtheexistenceofthetwobabies,bothgirls.Thereportsaidtheyandpeopleinvolvedinasecondpregnancyusingagene-editedembryowouldbecloselywatchedbygovernmenthealthagencies.Nothinghasbeensaidaboutthethirdpossiblebaby,whichshouldhavebeenborninlatesummer.ChineseofficialshaveseizedtheremainingeditedembryosandrecordsfromHe'slaboratory."Hecausedunintendedconsequencesinthesetwins,"Musunurusaidofthegeneediting."Wedon'tknowifit'sharmingthekids."WhoHelpedHe?ItisunclearwhoelsemayhavehelpedHeJiankuiinhisresearch.

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